Terpenes and Entourage

What Are Terpenes And Why Are They Important?

What are Terpenes then? Terpenes are a set of relative simple organic molecules present in all living organisms. Most aromas and flavors in a plant come from terpenes. Terpenes have a lot of power and Cannabis and other plants share many of the same terpenes. Terpenes are made up of carbon and hydrogen and are produced by many plants and also some insects. When they are dried, they are referred to as Terpenoids. They are the principle ingredient in plant resin or essential oils. Amongst many other very important roles they play in the plant and animal kingdom, they act as chemical building blocks for more complex molecules like cannabinoids and certain hormones.

As for most of the information and knowledge we received until now about Cannabis, we understand the medicinal and recreational part of it; or we are beginning to get a far deeper feel for the medicinal part. But we do not know much about the Aromatic side of Cannabis. Herbs in the kitchen are considered to be aromatic because of a certain terpene profile that gives the specific flavor. Cannabis on the other hand is so complex that possible terpene combinations are infinite which create a very broad spectrum of flavors and aromas.

The complexity of Cannabis terpenes leaves the door wide open for scientist to study and understand the benefit of these terpenes for us. Scientists could manipulate the desired ratio of cannabinoids in understanding certain terpenes.  It is to believe that certain terpenes modulate psychoactive and physiological effects of cannabis. The significant amount of the terpene beta-caryophellene (BPC) contributes to aroma and flavor of cannabis. It is found to activate the CBD2 receptor and acts as a non-psychoactive anti-inflammatory.

Regular users of cannabis often say that this weed they smoked was an upper, and another would be a downer. Interesting enough this is where terpenes are involved. Some strains are uplifting, others are sedating. Some would be a good painkiller, where another would be inspirational. I think it could be fine to say that good weed is more than the level of THC found in the bud. CBD has also been acknowledged to be part of the active ingredient. But it is so more complex than just these two components. The ultimate effect of cannabis is a fine balance between all the ingredients.

Then there are Flavonoids. This is what produces the unique flavor and aroma of cannabis. The flavonoids unique to cannabis are called Cannaflavins and apart from smelling terrific, they are also pharmacologically active. Cannaflavin-A has been discovered to inhibit the inflammatory molecule PGE-2 and reduce inflammation 30 times better than Aspirin.

The amazing variety in cannabis strains already is something to talk about. Now we are learning that terpenes interact with the other active compounds in cannabis. Terpenes cannot just modify how much THC travels through the blood-brain barrier; it also regulates neurotransmitters like serotonin and dopamine.

There are more than a 100 terpenes in cannabis, in fact closer to 200, but below are some of the profiles that might interest you.

 

  • Limonene
  • Myrcene- 
  • Linalool-
  • Delta 3 Carene-
  • Carryophyllene-

There are so much more to learn about the complexity of the cannabis plant. Researchers need to dig into terpenes now and map out different strains to identify the terpenes. Then they need to be clinically tested to understand the vast medical properties. It is an exciting time that lies ahead as more wonders of cannabis are discovered.

 

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The Importance of the Entourage Effect

Have you ever wondered why Simply CBD uses the whole plant instead of isolated cannabidiol (CBD)? It seems like a product touting that it is “Pure CBD” would be stronger right? In actuality, this could not be further from the truth.  Products using whole plant extract can be almost an order of magnitude stronger than isolated CBD.  The importance of the entourage effect comes into play.

For example, we have some people who are using Simply CBD that were previously using isolated CBD. When using CBD isolate, they were dosing 200mg. After switching to Simply CBD, they reported feeling relief from just 20mg CBD. The reason for this increased strength is a powerful synergistic interaction that takes place. This effect is known in the cannabis arena as the “entourage effect”. The entourage effect refers to the positive interaction of the almost 480 natural compounds unique to Cannabis sativa L .  This includes 66 cannabinoids120 terpenes and a whole host of other potentially beneficial substances present in the whole plant which are removed when using isolated “pure” CBD.

Many of these compounds are beneficial in their own right. They can also work together with CBD boosting its efficacy. This effect is what allows those using a whole plant product to use significantly smaller doses.  This means the benefits are comparable to a much larger dose of isolated CBD. Whole plant products also garner added benefits of the other important compounds present in the Cannabis sativa L plant.

Products using whole plant extract can be almost an order of magnitude stronger than isolated CBD.

“Entourage effect” is a term first used by Dr. Raphael Mechoulam, a brilliant organic chemist. He was the first person to be able to isolate not only CBD, but also its better known relative Δ9-tetrahydrocannabinol (THC) way back in 1963! Dr. Mechoulam has also headed up research on the endogenous cannabinoid system.  His postdoctoral researchers isolated a compound we all have in our bodies; a compound which he dubbed anandamide (from the sanskrit ananda meaning bliss). This compound itself could be effective in the treatment of depression and anxiety. It is also mimicked by CBD and other cannabinoids in the brain .

 

 

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